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Veeri Rajesh

Everything You Wanted To Know About Calcium Citrate

Calcium is a mineral nutrient with vital roles in the metabolic process. Supplied in the form of soluble citrates, these minerals can be conveniently incorporated into nutritional beverages.

Citrate is naturally occurring substance in the body, a metabolic product formed at the beginning of the energy cycle. During the tricarboxylic acid cycle, carbohydrates, fatty acids and proteins are broken down to provide energy. Citrate is also important in plants where inorganic calcium and magnesium salts are taken from the soil and converted into their citrates. Several plant foods therefore contain these citrates.
 
Calcium Citrate:

  • This is a bioavailable form of calcium, suitable for use as a supplement in enriched beverages and other food products where solubility is critical. Bioavailability describes the fraction of the nutrient absorbed by the body and available for further use.
  • Since the 1930’s, when nutritional studies were done in Scottish school children, it has been generally accepted that adequate amounts of dietary calcium are necessary for normal bone growth and development in children.
  • Since the 1970’s when osteoporosis became the subject of intensive medical research; the importance of adequate calcium nutrition particularly in postmenopausal women has been greatly emphasized. Extensive research has focused on whether calcium may slow or prevent age-related bone thinning. Most studies find that calcium supplementation does slow the loss of bone density, and numerous intervention studies document a decrease in fractures in postmenopausal women and older men given calcium supplements.
  • The calcium Dietary Reference Intake for adults older than 50 was raised in 1997 from 1,000 to 1,200mg to reflect new information about calcium’s role in bone health2.
  • High calcium intake also reduces the recurrence rate of colonic or rectal tumors, especially in women with high fat diets. Although no one is sure why calcium appears protective, it may be that it binds with potentially carcinogenic fatty acids and bile, rendering them harmless3.
  • A recent study with 441 women found a 1,200mg calcium supplement decreased most premenstrual symptoms by 48%. It should be noted that the placebo group reported a 30% decrease in PMS symptoms4.

 

U.S. Calcium Dietary Reference Intakes, 19971

Group                                     Adequate intake (mg/day)

Infants

Birth – 6 moths                       210

6 months – 1 year                   270

Children

1 – 5 years                               500

4 – 8 years                               800

Adolescents

9 – 18 years                                      1,300

Adults

19 – 50 years                           1,000

Over 50 years                          1,200

Pregnant & Lactation (no extra needed)

14 – 18 year         s                           1,300

19 & over                                1,000
 

References:

  1. Patrick, L. Altern Med Rev. 1999 Apr; 4(2):74-85
  2. Sterling, M. Nutrition Science News, February 2000
  3. Hyman, J, Baron JA. 1998 Apr; 7(4):291-5
  4. Thys-Jacobs S, Starkey P. Am J Obstet Gynecol 1998 Aug; 179(2):444-52

Calcium Sennosides | A Powerful Natural Laxative

Sennosides are hydroxyanthracene glycosides derived from Senna leaves. They have been used as natural, safe time-tested laxatives in traditional as well as modern systems of medicine. Senna is native to tropical Africa but now cultivated extensively in South of India. It is grown from seeds. The leaves are picked before or while plant is in flowering stage and pods are collected when they are ripe.
 

Summary:

Calcium sennosides has been used as a natural, safe time-tested laxatives in traditional as well as modern systems of medicine. Calcium sennosides is recognized for its laxative properties. A daily dose of sennoside B from 20 to 30 mg is recommended for this purpose

Botany Cassia acutifolia is native to Egypt and the Sudan while Cassia angustifolia is native to Somalia and Arabia. Plants known as “wild sennas” ( C. hebecarpa Fern. and C. marilandica L.) grow on moist banks and woods in the eastern US. This plant should not be confused with “cassia,” a common name for cinnamon. Senna is a low branching shrub, growing to about 3 feet in height. It has a straight woody stem and yellow flowers1 . The top parts are harvested, dried and graded. The hand-collected senna is known as Tinnevally senna. Leaves that have been harvested and graded mechanically are known as Alexandria senna. There are over 400 known species of cassia .

Calcium Sennosides

Senna was first used medicinally by Arabian physicians as far back as the 9th century A.D1 . It has long found use in traditional Arabic and European medicine as well, primarily as a cathartic. The leaves have been brewed and the tea administered for its strong laxative effect. Because it is often difficult to control the concentration of the active ingredients in the tea, an unpredictable effect may be obtained. Therefore, standardized commercial dosage forms have been developed, and these concentrates are available as liquids, powders and tablets in overthe-counter laxatives. The plant derives its name from the Arabic “sena” and from the Hebrew word “cassia,” which means “peeled back,” a reference to its peelable bark. Senna leaves are tested before and after grinding for Sennosides contents and are extracted with alcohol. The alcohol extract is converted to Calcium sennosides by addition of Calcium salt. Calcium sennosides is recognized for its laxative properties. Senna leaves or pods have been used as a cathartic laxative at doses of 0.6 to 2 g/day, with a daily dose of sennoside B from 20 to 30 mg. Senna is not recommended to be used at higher doses or for extended periods of time.
 

Clinical data

Many reports are available discussing senna’s role in constipation16,17, its use in the elderly18,19,20,21,22, in psychiatric patients23, in spinal cord injury patients24 and in pregnancy, where it is the stimulant laxative of choice25. In cancer treatment protocols, senna has also been noted to reverse the constipating effects of narcotics, and may prevent constipation if given with the narcotic26. It may, however, cause more adverse effects than other laxatives, primarily abdominal pain27. Senna has also been studied in chronic constipation28, Castor oil was superior to senna for chronic constipation sufferers in another report29 . Senna may affect influence on intestinal transit time30,31,32. Its effectiveness as part of a cleansing regimen to evacuate the bowels in preparation for such tests as colonoscopies or barium enemas is documented33,34,35,36,37,38,39,40,41,42,43. Results from these studies include reduced ingestion of commercial Golytely solution and simethicone when given with senna38 , and more effective colon cleansing with senna in combination with polyethylene glycol electrolyte lavage solution, compared to the solution alone39. Several mechanisms are postulated as to how senna acts as an effective laxative. The anthraquinone glycosides are hydrolyzed by intestinal bacteria to yield the active, freed anthraquinones. Alternately, it has been suggested that anthraquinones are absorbed in small quantities from the small intestine and hydrolyzed in the liver. The resultant anthraquinones are secreted into the colon44. One report using human intestinal flora finds sennoside A to eventually be converted to rheinanthrone, which is the active principle causing peristalsis of the large intestines. Sennosides A and B also play a role in inducing fluid secretion in the colon. Sennosides irritate the lining of the large intestine, causing contraction, which results in a bowel movement approximately 10 hours after the dose is taken1 .
 

Dosage

Senna leaves or pods have been used as a cathartic laxative at doses of 0.6 to 2 g/day, with a daily dose of sennoside B from 20 to 30 mg. Senna should not be used at higher doses or for extended periods of time46

Getting the Most Out of Your Health Food Supplements and Vitamins or Minerals with Black Pepper Extract

Black pepper was well known to the ancient world. It first appeared in the Sanskrit literature of India some 3,000 years ago. The first Westerner who is known to have encountered black pepper was Alexander the Great when he marched to the Punjab region in northern India in 326 B.C. He sampled it in some food under the local name of pippali. This spice was eventually exported to the Persians who had difficulty pronouncing the Indian name for it. A name change came about under King Darius who issued a royal edict for everyone to start calling it pipari instead. Our present word pepper is a derivation of that.

It was the Romans, however, who really gave pepper its major push in the culinary arts — they seasoned just about everything with it, including believe it or not, bread, milk and cheese! Black pepper was a much appreciated spice during antiquity. In 408 A.D., when Rome was besieged by Alaric, king of the Visigoths, he demanded a huge price for sparing the city: 4,000 fine garments, 2,500 kilograms of gold, 15,000 kilograms of silver and 2,500 kilograms of black pepper. His soldiers apparently enjoyed pepper — just as those from Genoa did in 1101 A.D. when they conquered Caesarea in the Levant and were rewarded with one kilogram of black pepper each.

During much of the Middle Ages, it served as “hard currency.” Some people stored it under lock and key as a measure of their fortunes and a man’s liquidity could be judged by his pepper assets. A proper annual bribe from a merchant to a tax-collector in Venice was considered to be one pound of pepper, cinnamon and ginger.

Medieval consumption of black pepper grew in amazing proportions. No longer was it just for the well-to-do, but became affordable even for the poor. Pepper even spread to the peasant classes and eventually influenced their cooking a lot. The taste for pepper was largely due to the miserable foodstuffs in the kitchens of that time — salted pork, more or less rotten beef (during the summer) and fish that had been out of the water for awhile. These stale materials were hidden under the heaps of pepper.

But court physicians who treated royalty then for a variety of health distresses, observed that whenever their subjects consumed strongly peppered meals, they experienced considerably fewer gastrointestinal problems. This prompted doctors to investigate the medicinal aspects of black pepper further. Meal digestion was largely improved and food assimilation greatly enhanced with the addition of small amounts of black pepper to each prepared dish.

When research scientists at Sabinsa Corporation became aware of this historical information, they wondered if black pepper might not do the same thing for health supplements as it had done with food for many centuries. There has always been a problem connected with the absorption of ingested nutrients in that certain amounts are “lost” or never fully utilized by the body. A number of different factors are responsible for this, which can become rather expensive to compensate for over a period of time. Individual consumers may be proned to buy additional units of their favorite nutritional supplements to make up for this inadequate absorption.

But now there is a real solution to this vexing and costly problem. Sabinsa Corporation discovered that a 95% purified extract of an important alkaloid from black pepper can enhance the bioavailability of many nutrients with virtually no loss to them in the body. It is known as Bioperine® and has been awarded two US Patents. Its active constituent, Piperine, is what gives pepper its unique pungency. This remarkable warming sensation in the gut, enables not only food, but also nutrients in supplemental form to be more readily absorbed and put to use.

A number of scientific experiments have proven this to be so time and again. When Bioperine® was administered orally to healthy humans in a dose of five milligrams per person per day, the serum levels of different tested nutrients significantly increased. Blood levels of fat-soluble beta carotene, for instance, when taken with Bioperine® for two weeks, increased by 60% over the control values, receiving the vitamin alone. When one of the B-Complex groups, Vitamin B-6 was ingested with Bioperine® it resulted in 2.5 times higher blood levels in only two hours. Furthermore, a six week supplementation program of selenium (in the form of selenomethionine) with and without this incredible ingredient, resulted in a 30% increase in serum levels of selenium in the Bioperine® group as compared to the control group. A recently completed human study involving the simultaneous administration of Bioperine® with CoQ10 yielded an absolute increase in blood serum levels of 30% as well.

The manner in which this amazing thermonutrient from pepper works, can best be explained to lay people using a comparative illustration, devoid of scientific jargon. Think of your body like a house with different rooms for leisure (brain and nerves); the kitchen for eating (stomach), the bathroom and laundry room for cleaning (colon, kidneys, liver and spleen), and so forth.

Now in each of these rooms or body compartments, there are separate thermostats for adjusting or regulating temperature. What Bioperine® does is to slightly increase the heat through a process known as thermogenesis. When this happens, the assimilation and utilization of ingested nutritional supplements become more complete or total. Your body can certainly use a boost whenever vitamins or minerals are taken. Bioperine® is the right ingredient for the job.
 

Bioperine® is a registered trademark of Sabinsa Corporation.

US Patents #5,536,506, 5,744,161, 5,972,382, and 6,054,585. Worldwide patents pending.

 

 

 

A Little Known Ingredient For Joint Pain

Joint pain is a very big problem for many people.  Looking for relief, they turn to products such as Advil and other over the counter pain killers.  However, for the long-term the use of these products is not the best for your health.  Therefore, some dietary supplements such as glucosamine and similar are marketed to help reduce joint pain.  But most people have never heard of a high quality product from India called AKBBA.  This ingredient could prove to be just what you are looking for to help with your joint pain.

Frankincense, also known as olibanum, is the resin from the trees of the genus Boswellia, native to Arabia and India. Its medicinal properties, in addition to use in religious ceremonies and for perfume production, have been appreciated for millennia.

In India, the gum resin exudates of Boswellia serrata, known in the vernacular as “Salai guggal”, has been used in the Ayurvedic system of medicine in the management of several inflammatory disorders.
 

Key Benefits

AKBBA MAX® is a composite of potent ingredients like Boswellin® (90% acetyl-11-keto-β-boswellic acid, AKBBA) and Boswellin® PS (10% AKBBA) by Sabinsa. Owing to the unique mechanism of action, this formula is known to help support and manage various inflammatory heath conditions, such as joint pain, arthritis.

This blend extracted from gum resin exudates from Boswellia serrata tree is a potent joint health formula for immediate relief with prolonged release time of the AKBBA component due to the presence of more water-soluble BOSWELLIN PS.

  • AKBBA MAX is perfect for those people who lead an active lifestyle to prevent or support post-exercise joint discomfort or for those who simply have joint pain
  • Presence of BOSWELLIN PS would result in faster and immediate relief until the effects of the other Boswellic acids begin to kick in, because most Boswellia actives are not water-soluble and work more slowly in the body
  • Long-term use of AKBBA MAX does not pose to the risk of gastric irritation and ulcers, unlike over-the-counter NSAIDS, like phenylbutazone

AKBBA MAX contains bioavailability enhancer, BioPerine®, a patented extract from black pepper standardized to contain 95% Piperine

  • BioPerine increases the absorption of the Boswellic acids in AKBBA MAX to make it a better natural anti-inflammatory joint health formula

 

Mechanism of Action:

The anti-inflammatory properties of the gum resin attributes to the presence of boswellic acids, which include β-Boswellic Acid (I) 3-O-Acetyl-β-Boswellic Acid (II) 11-Keto- β -Boswellic Acid (III) and 3-O-Acetyl-11-keto- β -Boswellic Acid (IV). Of these, 3-O-Acetyl-11-keto-β-boswellic acid (AKBBA) is reported to be the most potent anti-inflammatory molecule.

Dual mechanism of boswellic acids involving inhibition of enzymes like 5-lipoxygenase (5-LO) and human leukocyte elastase (HLE), which are involved in formation of leukotrienes―key compounds involved in joint inflammation is believed to be unique as compared to NSAIDs.

Boswellic acids also work in the more conventional way to block inflammation from the COX-2–PGE2 pathway, the inflammatory target of aspirin, ibuprofen and other NSAIDs.

Clinical evidence is present in a few cases to validate effectiveness of boswellic acids in countering inflammation in arthritis patients.

 

Maintaining Intestinal Health With The Use of Probiotics

LactoSpore

What is LactoSpore?

  • LactoSpore is a superior probiotic, which is room-temperature stable and does not require refrigeration
  • Sabinsa’s LactoSpore is a spore of probiotic bacterium, Bacillus coagulans formerly known as Lactobacillus sporogenes
  • Sabinsa’s LactoSpore is Generally Recognized As Safe (GRAS)

What is probiotics?

  • Probiotics are live microorganisms, which, when administered in adequate amounts, confer a health benefit on the host. (Guidelines for the Evaluation of Probiotics in Food, FAO/WHO)
  • Probiotics support the immune system, digestive system and general health

What live organisms are in probiotics?

  • Non-pathogenic or “good” bacteria
  • Probiotic microbes are assessed by the selection criteria of Guidelines for the Evaluation of Probiotics in Food (FAO/WHO, 2002)

What are the base requirements for good bacteria as functional probiotics?

  • Identification at strain level of the microorganism by the most current methodology including a combination of phenotypic and genetic tests
  • Strains must be deposited in an internationally recognized culture collection
  • in vitro tests to detect physiological and functional health potentials of the strain
  • In vivo trials to confirm efficacy in humans and animals

Does LactoSpore satisfy these base requirements?

  • Yes,LactoSpore meets base requirements of probiotics for food and it is superior to other probiotics:
  • The strain of Bacillus coagulans is characterized by an external research laboratory: phenotypically and genetically
  • The strain of Bacillus coagulans has 99.5% of homology with Bacillus coagulans ATCC 7050 (The American Type Culture Collection serves as a worldwide repository and distribution center for cultures of standard reference microorganisms)
  • In vivo studies revealed probiotic properties of Bacillus coagulans, such as resistant spore to adverse environment, adherence capacity to intestinal mucosa, inhibitory activity against harmful bacteria and resistance to harsh conditions of manufacturing processes<\li>
  • Oral administration of Bacillus coagulans improved daily weight gain and mortality in chickens and piglets and inhibited vancomycin-resistant enterococci colonization in mice
  • In humans, a preparation of Bacllus coagulans alleviated clinical symptoms of a variety of health conditions including chronic and acute catarrhal enteritis, diarrhea, constipation, abnormal intestinal fermentation, dyspepsia infantum, neonatal diarrhea, lactose intolerance, non-specific vaginitis and urinary tract infections

Why is LactoSpore superior to other probiotics?

  • Bacillus coagulans is the only spore-forming probiotic. Spore-forming gram- positive bacteria including Bacillus coagulans form a spore, a temporary non-reproductive structure, which consists of the entire hereditary information enveloped by a resistant outer coating. Spores can survive without nutrients and they are extremely resistant to adverse factors, such as ultraviolet radiation, desiccation, high temperature, freezing and chemicals. Spores can survive for extended periods because of resistance. They reactivate to the vegetative form when the environment is favorable
  • Therefore, LactoSpore
  • Maintains viability during preparation and storage until consumption
  • Keeps viability during the manufacturing process
  • Survives the acidity of stomach and bile acids and digestive enzymes
  • Germinates in the intestine, which is favorable for Bacillus coagulans spore reactivation

Does the vegetative form inhabit in the intestine?

  • No, the vegetative form of Bacillus coagulans is transient. In other words, the bacterium does not inhabit the intestine permanently.

How long does the bacterium stay at the intestine?

  • It is dose-dependent. Healthy adults who were administered 2.5g of probiotics containing 108 spores of Bacillus coagulans per gram daily for 10 days were free of the bacterium at the 6th day after the treatment was discontinued (Hashimo, K. et al (1964) New Drugs and Clinics 13 (9): 53-66

What are the probiotic functionalities of the vegetative form of Bacillus coagulans?

  • Restricts the growth of harmful microbes competing for nutrients and environment in the gut
  • Generates the acidic microenvironment that is harmful for manypathogenic or “bad” microbes by fermenting polysaccharides
  • Produces bacteriocin-like substances
  • Produces L(+) lactic acid only
  • Helps lactose-intolerance
  • Promotes the innate and adaptive immunity
  • Alleviates digestive discomforts
  • Supports the liver
  • Prevents colonic dysbacteriosis that is caused by antibiotic therapy, surgery, chemo or radiation therapies and unhealthy diets

What are health conditions and clinical symptoms that LactoSpore may help?

LactoSpore primarily promotes the healthy digestive tract. Therefore, LactoSpore relieves and complements therapies of conditions:

  • Diarrhea*
  • Dysbacteriosis*
  • Lactose intolerance*
  • Digestive discomfort (flatulence, indigestion, cramps, heart burn, bloating and stomach pain)*
  • Gastrointestinal infections*
  • Constipation*
  • Acute and chronic gastroenteritis*
  • Inflammatory disorders of the intestine: Inflammatory bowel disease (IBD) and Irritable bowel syndrome (IBS)*
  • Immunodeficiency*

Is LactoSpore safe?

  • Yes, Bacillus coagulans is non-pathogenic and is temporarily resident in the gut
  • No report data on side effects and toxicity

Is LactoSpore GMO?

  • No, LactoSpore is not genetically-modified organism

What about BSE/TSE status?

  • LactoSpore is BSE/TSE free

What about Kosher and Halal certifications?

  • Sabinsa’s ingredients are Kosher- and Halal-certified

What about gluten and wheat?

  • LactoSpore is gluten-free and wheat-free

  Is LactoSpore an ODI (Old Dietary Ingredient)?

  • Yes, LactoSpore is an Old Dietary Ingredient
  • LactoSpore can therefore be marketed immediately, without the need for pre-market NDI notification

What is the suggested daily dose?

  • The suggested dose is 100-200 million organisms per dose-3 times daily
  • It is in powder form

What are suggested available forms of delivery?

  • LactoSpore can be prepared in forms of tablets, capsules, chewable tablets, yogurts and functional foods.

How many spores per gram are in Sabinsa’s LactoSpore?

  • Sabinsa offers LactoSpore in 6 billion and 15 billion spores per gram

How is the viability of spores guaranteed?

  • Samples of finished products are tested by identification tests,viable Bacillu coagulans spore count,lactic acid producing capacity,stability and contamination

What is the shelf life of LactoSpore?

  • Sabinsa’s LactoSpore does not require specific conditions for storage like other probiotics
  • Bacillus coagulans spores are stable for a long time. The current LactoSpore has 2 years’ shelf life at room temperature (15oC to 25oC)

Is LactoSpore manufactured in a GMP facility?

  • Sabinsa’s raw material manufacturing facilities (located in India) are operated according to cGMP
  • These facilities are FDA-inspected

Where I can find more information on LactoSpore?

* These statements have not been evaluated by the Food and Drug Administration. These products are not meant to diagnose, treat, cure, mitigate or prevent any disease or medical condition.

How To Make Your Nutrients More Available In Your Body

Bioperine is a black pepper extract that can be used to make nutrients more available in one’s body.  

What is Bioperine?

  • BioPerine is a natural ingredient, which significantly improves bioavailability and benefits of nutritive compounds
  • BioPerine is a patented standardized extract from the fruits of Piper nigrum (black pepper)
  • BioPerine is GRAS (Generally Recognized As Safe)

What is the active ingredient?

  • The active ingredient is piperine, a pungent alkaloid

How pure is BioPerine?

  • BioPerine contains 95 to 99% pure piperine

Why is BioPerine superior to black pepper?

  • Piperine content in BioPerine is much higher (95-­99% pure piperine) than it is in black pepper; Piperine is only 3-­9% in all parts of black pepper
  • A standardized extract allows a wide range of applications other than the traditional use of black pepper

What are the potential nutraceutical benefits of BioPerine?

  • BioPerine offers a wide range of health benefits. Improving the bioavailablity of nutritional substances is the primary benefit among them

How does piperine enhance the bioavailability of nutritive substances?

There are a few theories about BioPerine’s mechanism of action:

  • Piperine interferes with substance-­converting enzymes, such as UDP-­glucuronyltransferase in the small intestine and liver. The excretion of the nutritional ingredients by the kidneys is blocked because the natural state of the nutritional ingredients is less soluble and their excretion through the urine is less efficient
  • Vanilloid receptors are G protein coupled and highly expressed on afferent neurons of the gastrointestinal (GI) tract. Piperine binding to vanilloid receptors activates membrane‐bound adenyl cyclase, which catalyzes the synthesis of the second messenger molecule cAMP. cAMP activates protein kinase A (PKA) that inhibits intestinal motility and dilates blood vessels of the intestine. This physiological action may cause better digestion and absorption
  • Piperine is likely to facilitate the absorption of nutrients interacting with the ultrastructure of intestinal brush border and stimulating digestive enzymes

What nutritional ingredients’ bioavailability is enhanced by BioPerine?

BioPerine has been shown to enhance the bioavailability of the following groups of nutrients in humans and animals:

  • Resveratrol
  • Herbal extracts (curcumin, ashwaganda, capsaicin, Gingko biloba)
  • Water soluble vitamins (vitamin B1, B2, B6, B12, niacinamide, folic acid and vitamin C)
  • Fat-­soluble vitamins (vitamin A, D, E and K)
  • Antioxidants (vitamin A, C, E,alpha-­‐carotene, transbeta­‐carotene, lycopene, lutein/zeaxantin, pine bark bioflavanoids complex, germanium, selenium and zinc)
  • Amino acids (lysine, isoleucine, leucine, threonine, valine, tryptophan, phenylalanine and methionine)
  • Minerals (calcium, iron, zinc, vanadium, selenium, chromium, iodine, potassium, manganese, copper and magnesium)

Is the bioavailability of all of these ingredients tested in humans?

The bioavailability of resveratrol, selenomethionine, vitamin B6 and C, CoQ10, beta carotene and curcumin were evaluated in humans with the administration of Sabinsa’s BioPerine as follows:

  • One group of people took the ingredients with BioPerine
  • The other group took the ingredients alone
  • The blood levels of the ingredients were significantly higher among those who have taken the ingredients with BioPerine.
  • The study was conducted in the US among healthy volunteers

What about piperine’s impact on drug bioavailability?

  • Piperine may or may not affect drug bioavailability. For instance, piperine improves the bioavailability of ampicillin and norfloxacin, which are antibiotics with low oral bioavailability. It certainly depends on drug chemistry and pharmacokinetics. Therefore, this should be discussed with your physician or health care provider

What are the other physiological effects of piperine?

Extensive data is collected reporting black pepper’s health benefits other than natural bioenhancer properties, such as

  • Antidepressant *
  • Antiapoptotic *
  • Antioxidant *
  • Anti-­platelet effect *
  • Asthma relieving *
  • Anti-­inflammatory activity *
  • Antihypertensive effect *
  • Hepatoprotective effect *
  • Antithyroid effect *
  • Fertility enhancer *
  • Antitumor activity *

Is the plant sustainably harvested?

  • Yes, piperine is extracted from sustainably‐grown Piper nigrum

Is BioPerine GMO?

  • No, BioPerine is not genetically-­modified

What about Allergen­‐free, Kosher and Halal certifications?

  • Sabinsa’s most ingredients are Kosher and Halal certified as well as Allergen free

Is BioPerine an ODI (Old Dietary Ingredient)?

  • Yes, BioPerine is an Old Dietary Ingredient.
  • BioPerine can therefore be marketed immediately, without the need for pre‐market NDI notification

What is the suggested daily dose?

  • The suggested dose is 5 mg 3 times daily.

Is BioPerine manufactured in a cGMP facility?

  • Sabinsa’s manufacturing facilities are cGMPand located in India
  • They are FDA‐inspected and passed

Is Sabinsa’s BioPerine patented?

Where I can find more information on BioPerine?

* These statements have not been evaluated by the Food and Drug Administration. These products are not meant to diagnose, treat, cure, mitigate or prevent any disease or medical condition.

Support Hydration & Healthy Cell Growth With Coconut Water

Coconut water, the liquid endosperm of green coconuts (Cocos nucifera), is a refershing natural beverage, an oral rehydrating agent, and a supplement in nutrient media for tissue culture.  Coconut water is often described as a “natural isotonic sports drink”, providing higher amounts of electrolytes such as potassium and magnesium than conventional sports drinks.  Coconut water solids also have a probiotic role, and beneficially influence the balance of microflora in the gastrointestinal tract.  When topically applied, coconut water solids nourish the skin and hair, supporting healthy cell growth.

Citrin: Clear the standard for (-)HCA

What is Citrin?

In 1991, Citrin was introduced to the health food industry as the first all-natural plant extract standardized for hydroxycitric acid.  This unique extract comes from premium, hand-harvested, Garina cambogia fruits grown int he selected regions of southern India.  The active principle of Citrin, hydroxycitric acid, is in the rind of the Garcinia cambogia.

 

What is HCA?

HCA stands for (-)-hydroxycitric acid.  Hoffman-LaRoche, an international pharmaceutical company, and Brandeis Universityresearchers began investigating HCA in the early 1970’s.  THey found that the (-) form of HCA was a potent and competitive inhibitor of citrate lyase, an enzyme found primarily in the liver which is vital in regulating fat metabolism.

 

How does HCA work?

Fatty acids are the building blocks of fats and lipids.  At the cellular level, (-) HCA molecules trick the citrate lyase enzyme.  The receptor sites of citrate lyase enzymes are filled with (-) HCA.  This means fewer fatty acids are synthesized, making less fat available for the cellular storage.  This results in less body fat build-up in the liver and adipose (fat) tissue.  Increased amounts of energy at the celluar level are then available to more rapidly degrade free fatty acids.

Is this all?

No….(-) HCA suppresses the app

Top Reasons To Use A High Quality Curcumin Supplement

When it comes choosing the correct curcumin supplement, you want to make sure that the one you chose is of the highest quality.  There are to many low-quality curcumin supplements that are being sold today.  Therefore, here are the top 10 things to look for when you want to buy a curcumin supplement

  1.  Make sure that it has a patent.  When the curcumin that you buy has a patent, that means it is very high quality.  For example, the curcumin that we use in our curcumin product  is patent number 5,861,415.  As you can see our founder’s name, Dr. Majeed’s, name is on the patent. 
  2.  

  3.  Make sure that it is derived from a standardized extract of turmeric root ( 95% Curcuminoids C3 complex) which are known to both prevent the formation of free radicals and to neutralize existing free radicals, making them dual-action “bio-protectants”.
  4. Safety.  Be sure that the curcumin has been reviewed and acknowledge by the USFDA for GRAS status, a process which includes a comprehensive review of safey and toxicology data.

  5.  When possible make sure the curcumin is co-administered with Bioperine ( 20mg), because it supports an enhanced effect without any adverse side effects.

 

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